Clinical Research
Dr Shanmuganathan is actively involved in clinical research. He serves as the principal investigator for clinical heart failure. He works with large research teams and will try to offer every patient a chance to participate in research.
He has published in peer-reviewed international journals and medical text books.
Research Publications
Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial
A Morrow, R Young, GR Abraham, S Hoole, JP Greenwood, JR Arnold, ...Circulation 2024
M Shanmuganathan, C Nikolaidou, MK Burrage, A Borlotti, R Kotronias, ...JACC Cardiovascular Imaging 17 (9), 1044-1058 22024
Clinical Significance of Myocardial Injury in Patients Hospitalized for COVID-19: A Prospective, Multicenter, Cohort Study H Shiwani, J Artico, JC Moon, M Gorecka, GP McCann, G Roditi, ...
JACC: Cardiovascular Imaging 12024
The role of coronary blood flow and myocardial edema in the pathophysiology of takotsubo syndrome LS Couch, KE Thomas, F Marin, D Terentes-Printzios, RA Kotronias, ...JACC Cardiovascular Imaging 17 (7), 835-83722024
M Shanmuganathan, C Nikolaidou, M Burrage, A Borlotti, E Gara, ...Heart 110 (Suppl 3), 193-195
2024
G Gallone, J Ibero, A Morley‐Smith, M Monteagudo Vela, F Fiorelli, ... Journal of the American Heart Association 13 (9), e032617 12024
M Shanmuganathan, R Gonzales, M Burrage, P Arvidsson, A Banerjee, ...Journal of Cardiovascular Magnetic Resonance 26 2024
M Shanmuganathan, C Nikolaidou, M Burrage, A Borlotti, R Kotronias, ...Journal of Cardiovascular Magnetic Resonance 26 2024
Rationale and design of the United Kingdom heart failure with preserved ejection fraction registry
UK HFpEF Collaborative Group Heart 110 (5), 359-365 32024
KE Thomas, E Lukaschuk, M Shanmuganathan, JA Kitt, IA Popescu, ... European Heart Journal-Cardiovascular Imaging 25 (3), 339-346 2024
GSD Purvis, M Collino, AD van Dam, G Einaudi, Y Ng, ... Diabetes 12024
C Berry, A Morrow, G Abraham, S Hoole, J Greenwood, J Arnold, ...12023
PM Arvidsson, PG Green, WD Watson, M Shanmuganathan, E Heiberg, ... European Heart Journal-Imaging Methods and Practice 1 (2), qyad035 72023
S Gurunathan, M Shanmuganathan, A Chopra, J Pradhan, L Aboud, ... European Heart Journal Open 3 (3), oead053 42023
Post-COVID-19 cardiovascular sequelae
DG Condurache, M Shanmuganathan, Z Raisi-Estabragh, B Raman Frontiers in Cardiovascular Medicine 10, 119195342023
G Gallone, JI Valencia, A Morley-Smith, O Dar, MM Vela, F Fiorelli, ... The Journal of Heart and Lung Transplantation 42 (4), S451-S452 2023
FR Gil, G Gallone, A Morley-Smith, O Dar, JI Valencia, MM Vela, F Fiorelli, ... The Journal of Heart and Lung Transplantation 42 (4), S366-S367
Myocardial Involvement After Hospitalization for COVID-19 Complicated by Troponin Elevation: A Prospective, Multicenter, Observational Study. Artico J, Shiwani H, Moon JC, Gorecka M, McCann GP, Roditi G, Morrow A, Mangion K, Lukaschuk E, Shanmuganathan M...et al. Circulation. 2023 Jan 27;147(5):364-374.
Acute Response in the Noninfarcted Myocardium Predicts Long-Term Major Adverse Cardiac Events After STEMI; M SHANMUGANATHAN, A Masi, MK Burrage, RA Kotronias, A Borlotti, ...JACC: Cardiovascular Imaging 2022
Artificial Intelligence for Contrast-Free MRI: Scar Assessment in Myocardial Infarction Using Deep Learning–Based Virtual Native Enhancement; Q Zhang, MK Burrage, M SHANMUGANATHAN, RA Gonzales, E Lukaschuk, ...Circulation 146 (20), 1492-1503 2 2022
Case Series of Triathletes with Takotsubo Cardiomyopathy Presenting with Swimming-Induced Pulmonary Edema C Rigler, G Menon, S Lipworth, JP Langrish, C Kipps, R Smith, M SHANMUGANATHAN; Translational Sports Medicine 2022
TVnet: automated global analysis of tricuspid valve plane motion in CMR long-axis cines with residual neural networks for assessment of right ventricular function; RA Gonzales, J Lamy, KE Thomas, Q Zhang, M SHANMUGANATHAN, ...European Heart Journal-Cardiovascular Imaging 23 (Supplement_2), jeac141. 019 12022
Neuropeptide‐Y Levels in ST‐Segment–Elevation Myocardial Infarction: Relationship With Coronary Microvascular Function, Heart Failure, and Mortality; T Gibbs, N Tapoulal, M SHANMUGANATHAN, MK Burrage, A Borlotti, ... Journal of the American Heart Association 11 (13), e024850 3 2022
Neutrophils incite and macrophages avert electrical storm after myocardial infarction J Grune, AJM Lewis, M Yamazoe, M Hulsmans, D Rohde, L Xiao, ...M SHANMUGANATHAN,…;Nature cardiovascular research 1 (7), 649-664 6 2022
Invasive validation of pressure-volume loops derived from cardiovascular magnetic resonance imaging and brachial blood pressure in heart failure patients; P Arvidsson, P Green, W Watson, M SHANMUGANATHAN, E Heiberg, …Heart 108 (Suppl 1), A120-A121 2022
Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure LS Couch, J Fiedler, G Chick, R Clayton, E Dries, LM Wienecke, L Fu, ...M SHANMUGANATHAN…;Cardiovascular research 118 (7), 1758-1770 202022
Rapid neutrophil mobilization by VCAM-1+ endothelial cell-derived extracellular vesicles; N Akbar, AT Braithwaite, EM Corr, GJ Koelwyn, C van Solingen, ...M SHANMUGANATHAN…; Cardiovascular Research 2022
Fast and robust motion correction of cardiovascular magnetic resonance T1-mapping using data-driven convolutional neural networks for generalisability RA Gonzales, Q Zhang, BW Papież, K Werys, E Lukaschuk, IA Popescu, ...M.SHANMUGANATHAN…Society for Cardiovascular Magnetic Resonance 1 2022
Pressure‐controlled intermittent coronary sinus occlusion improves the vasodilatory microvascular capacity and reduces myocardial injury in patients with STEMI; R Scarsini, D Terentes‐Printzios, M SHANMUGANATHAN, RA Kotronias, ...Catheterization and Cardiovascular Interventions 99 (2), 329-339 5 2022
Development of deep learning virtual native enhancement for gadolinium-free myocardial infarction and viability assessment; Q Zhang, MK Burrage, M SHANMUGANATHAN, RA Gonzales, C Nikolaidou, ...Proceedings of the 2022 SCMR Virtual Annual Scientific Sessions 1 2022
Comparative and Integrated Analysis of Plasma Extracellular Vesicles Isolations Methods in Healthy Volunteers and Patients Following Myocardial Infarction; D Paget, A Checa, B Zohrer, M SHANMUGANATHAN, R Dhaliwal, E Johnson, ...medRxiv 2022
From anatomy to function and then back to anatomy: invasive assessment of myocardial ischemia in the catheterization laboratory based on anatomy-derived indices of coronary …GLDE Maria, S Wopperer, R Kotronias, M SHANMUGANATHAN, R Scarsini, ... Minerva cardiology and angiology 69 (6), 626-640 2021 Minerva Cardiology and Angiology 2021
TCT-455 Preprocedural ATI Score (Age–Thrombus Burden–Index of Microcirculatory Resistance) Predicts Long-Term Clinical Outcomes in Patients With ST-Segment Elevation Myocardial …C Montalto, R Kotronias, F Marin, D Terentes-Printzios, ...M.SHANMUGANATHAN...;Journal of the American College of Cardiology 78 (19_Supplement_S), B187-B188 2021
1 Long-term prognosis after acute ST-segment elevation myocardial infarction is determined by characteristics in both non-infarcted and infarcted myocardium on cardiovascular …M SHANMUGANATHAN, A Masi, MK Burrage, RA Kotronias, A Borlotti, ...Heart 107 (Suppl 3), A1-A1 2021
Coronary microvascular dysfunction assessed by pressure wire and CMR after STEMI predicts long-term outcomes; R Scarsini, M SHANMUGANATHAN, GL De Maria, A Borlotti, RA Kotronias, …JACC: Cardiovascular Imaging 14 (10), 1948-1959 15 2021
Pre-procedural ATI score (age-thrombus burden-index of microcirculatory resistance) predicts long-term clinical outcomes in patients with ST elevation myocardial infarction …C Montalto, RA Kotronias, F Marin, D Terentes-Printzios, ...M SHANMUGANATHAN…International Journal of Cardiology 339, 1-6 2 2021
Toward replacing late gadolinium enhancement with artificial intelligence virtual native enhancement for gadolinium-free cardiovascular magnetic resonance tissue …Q Zhang, MK Burrage, E Lukaschuk, M SHANMUGANATHAN, IA Popescu, ...Circulation 144 (8), 589-599 27 2021
In vivo grafting of large engineered heart tissue patches for cardiac repair; RJ Jabbour, TJ Owen, P Pandey, M Reinsch, B Wang, O King, LS Couch, ...M.SHANMUGANATHAN,...JCI insight 6 (15) 13 2021
Management of heart failure with reduced ejection fraction in 2021: an update for GPs; M SHANMUGANATHAN, R Goswami, O Dar; British Journal of General Practice 71 (708), 330-332 2021
Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods; MK Burrage, M SHANMUGANATHAN, Q Zhang, E Hann, IA Popescu, ... Scientific reports 11 (1), 1-13 6 2021
Cardiovascular magnetic resonance stress and rest T1-mapping using regadenoson for detection of ischemic heart disease compared to healthy controls; MK Burrage, M SHANMUGANATHAN, A Masi, E Hann, Q Zhang, IA Popescu, ...International Journal of Cardiology 333, 239-245 7 2021
Angiography-derived index of microcirculatory resistance (IMRangio) as a novel pressure-wire-free tool to assess coronary microvascular dysfunction in acute coronary syndromes …R Scarsini, M SHANMUGANATHAN, RA Kotronias, D Terentes-Printzios, ...The International Journal of Cardiovascular Imaging 37 (6), 1801-1813 24 2021
Predicting Significant Right Ventricular Failure Post-LVAD Implantation Using CMR Compared to Echocardiography and Right Heart Catheterisation; M SHANMUGANATHAN, P Rajani, E Androulakis, S Moledina, G Sarri, ...The Journal of Heart and Lung Transplantation 40 (4), S43 1 2021
Empagliflozin in heart failure; M SHANMUGANATHAN, RM Goswami; The New England journal of medicine 384 (4), 386 2 2021
Integrated omics for Plasma EV Diagnostics is Influenced by the Isolation Method; D Paget, R Heilig, M SHANMUGANATHAN, R Dhaliwal, E Johnson, A Checa, ...2021
MOCOnet: robust motion correction of cardiovascular magnetic resonance T1 mapping using convolutional neural networks; RA Gonzales, Q Zhang, BW Papież, K Werys, E Lukaschuk, IA Popescu,
M.SHANMUGANATHAN...;Frontiers in Cardiovascular Medicine 8 2 2021
Long-term clinical outcomes in patients with an acute ST-segment-elevation myocardial infarction stratified by angiography-derived index of microcirculatory resistance; RA Kotronias, D Terentes-Printzios, M SHANMUGANATHAN, F Marin, ...Frontiers in cardiovascular medicine 8 17 2021
Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge; B Raman, MP Cassar, EM Tunnicliffe, N Filippini, L Griffanti, ...M.SHANMUGANATHAN…;EClinicalMedicine 31, 100683 397 2021
A CMR first strategy in patients with suspected NSTEMI may help identify MINOCA and infarct related artery; M SHANMUGANATHAN, A Barlotti, R Scarsini, C Nikolaidou, E Gara, ...European Heart Journal-Cardiovascular Imaging 22 (Supplement_1), jeaa356. 255 2021
Rare congenital quadricuspid pulmonary valve stenosis evaluated by CMR; C Nikolaidou, M SHANMUGANATHAN, M Lacharie, S Myerson; Oxford Medical Case Reports 2020 (12), omaa112 2020
Rationale and design of the Medical Research Council's precision medicine with Zibotentan in microvascular angina (PRIZE) trial; AJ Morrow, TJ Ford, K Mangion, T Kotecha, R Rakhit, G Galasko, S Hoole, ...M.SHANMUGANATHAN...;American Heart Journal 229, 70-80 29 2020
COVID-19 and cardiac considerations in the community; M SHANMUGANATHAN, JC Leoni-Moreno; British Journal of General Practice 70 (700), 524-525 1 2020
Assessment of safety and renal function in ultrafiltration in patients with decompensated chronic heart failure with diuretic resistance; KK Saleh, P Bamania, M SHANMUGANATHAN, L Greswell, TP Chua; EUROPEAN JOURNAL OF HEART FAILURE 22, 96-96 2020
Angiography-derived index of microcirculatory resistance as a novel, pressure-wire-free tool to assess coronary microcirculation in ST elevation myocardial infarction; GL De Maria, R Scarsini, M SHANMUGANATHAN, RA Kotronias, ...The international journal of cardiovascular imaging 36 (8), 1395-1406 48 2020
Role of adjuvant carotid ultrasound in women undergoing stress echocardiography for the assessment of suspected coronary artery disease; S Gurunathan, M SHANMUGANATHAN, R Hampson, R Khattar, R Senior; Open Heart 7 (1), e001188 2020
ATGL Deficiency-Induced Triglyceride Deposit Cardiomyovasculopathy Requiring Heart Transplant: A 5-Year Follow-Up; P Rajani, JL Robertus, J Wong, T Homfray, FR Gil, M SHANMUGANATHAN; Case Reports 2 (5), 760-763 1 2020
UTILITY OF CARDIAC MRI IN PREDICTION OF ACUTE RIGHT VENTRICULAR FAILURE AFTER LVAD IMPLANTATION; S Moledina, M SHANMUGANATHAN, V Baston, A Tana, G Saari, JL Robertus, ...Journal of the American College of Cardiology 75 (11_Supplement_1), 1826-1826 2020
Endothelial Cell-Derived Extracellular Vesicles Elicit Neutrophil Deployment from the Spleen Following Acute Myocardial Infarction; N Akbar, AT Braithwaite, EM Corr, GJ Koelwyn, C van Solingen, ...medRxiv 2 2020
Complications of Heart Transplantation; M SHANMUGANATHAN, O Dar; Cardiac Surgery, 665-670 1 2020
Pressure-bounded coronary flow reserve to assess the extent of microvascular dysfunction in patients with ST-elevation acute myocardial infarction. R Scarsini, GL De Maria, M SHANMUGANATHAN, RA Kotronias, ...Eurointervention: Journal of Europcr in Collaboration with the Working Group … 1 2019
P1507 Role of adjuvant carotid ultrasound in women undergoing stress echocardiography for the assessment of suspected angina with no previous history of coronary artery disease; S Gurunathan, M SHANMUGANATHAN, R Hampson, R Khattar, R Senior; European Heart Journal 40 (Supplement_1), ehz748. 0269 1 2019
P5385 Development and preclinical testing of upscaled engineered heart tissue for use in translational studies; R Jabbour, T Owen, M Reinsch, P Pandey, B Wang, O King, G Smith, ... European Heart Journal 40 (Supplement_1), ehz746. 0345 2019
Spontaneous subdural haematoma in a patient with a total artificial heart on warfarin; S Moledina, M SHANMUGANATHAN, S Pathak, A Simon; BMJ Case Reports CP 12 (9), e230519 2 2019
Developments in Heart Failure: Mechanical Unloading with LVADs, Exosomes, and MicroRNAs; S Guymer, M SHANMUGANATHAN; Heart of the Matter, 167-177 2019
Exosomes: basic biology and technological advancements suggesting their potential as ischemic heart disease therapeutics; M SHANMUGANATHAN, J Vughs, M Noseda, C Emanueli; Frontiers in Physiology 9, 1159 37 2018
Longitudinal Exosomal and Tissue Expression of microRNA-208a and 208b in Acute and Chronic Rat Post-Myocardial Infarction Remodelling; SC Guymer, S Narodden, M SHANMUGANATHAN, P Punjabi, SE Harding; Circulation 138 (Suppl_1), A15875-A15875 2018
45 Ultrafiltration in decompensated chronic heart failure patients with diuretic resistance; K Saleh, M SHANMUGANATHAN, D Abdulrahman, N Findlay, L Greswell, ...; Heart 104 (Suppl 6), A42-A432018
Successful use of ultrafiltration (UF) in patients with heart failure (HF) and diuretic resistant fluid overload-A 3 year experience in a District General Hospital; M SHANMUGANATHAN, K Saleh, TP Chuah; EUROPEAN JOURNAL OF HEART FAILURE 20, 350-350 2018
Meta regression analysis of aortic reflection timing to locate the site of reflection and to identify its relationship with arterial stiffness and age in 8336 subjects; M SHANMUGANATHAN, AJ Baksi, DP Francis, TA Treibel, T Tillin, K Parker, ...Springer Nature 2010
A Periodic breathing: novel experimental models to develop dynamic therapies; R Baruah, A Giannoni, C Manisty, K Willson, Y Mebrate, A Kyriacou, ...; Heart 96 (Suppl 1), A1-A1 2010
3.1 NEW INSIGHTS INTO ARTERIAL STRUCTURAL-FUNCTIONAL INTERACTIONS AND THE IMPLICATIONS FOR PRESSURE AUGMENTATION IN HUMANS: A META REGRESSION ANALYSIS IN 8336 SUBJECTS; M SHANMUGANATHAN, AJ Baksi, T Treibel, T Tillin, DP Francis, J Mayet, ...Artery Research 4 (4), 146-146 2010
Caution using brachial systolic pressure to calibrate radial tonometric pressure waveforms: lessons from invasive study; JE Davies, M SHANMUGANATHAN, DP Francis, J Mayet, DR Hackett, …;Hypertension 55 (1), e4-e4 33